Since any UIView can be a hotspot, you can add any UIControl or add any UIGestureRecognizer to your hotspot and make it fully user interactive. You can also take advantage of the convertPoint/Rect:from/toView: UIView methods and show popovers from a hotspot as seen in the demo project:
[popover presentPopoverFromRect:hotspot.frame inView:hotspot.superview permittedArrowDirections:UIPopoverArrowDirectionAny animated:YES];
There's also a new property for UIView shouldApplyPerspective. It indicates if the hotspot should be rendered always parallel to the screen (shouldApplyPerspective==NO) or perpendicular to the point-of-view/hotspot axis (shouldApplyPerspective==YES; default value).
You can get the code from the repository at bitbucket.